MyBioSource.com's TNF-R1 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunofluorescence, Immunohistochemistry, and Western Blot. The TNF-R1 Antibody was generated using CD120a, MS5, TNFalpha-R1, TNFR1, TNFRI, and TNFRSF1A as the antigen and it reacts with Human, Mouse, and Rat.
Description
TNF-a is an important cytokine produced by numerous cell types including neutrophils, activated lymphoctyes, macrophages an NK cells. It plays a critical role in inflammatory responses and in apoptosis (1). TNF-a exists as a membrane-anchored and soluble form, both of which show biological activity. Response to TNF-a is mediated through two receptors, TNF-R1, which is widely expressed, and TNF-R2, which is expressed mainly in immune and endothelial cells (2). Antagonists to TNF-a have been validated as therapeutic targets for rheumatoid arthritis and other immune disorders (3)